One in 25 persons of European descent carries one Z allele (Glu342Lys) instead of two wild‐type M alleles, which culminates in homozygosity, coined the protease inhibitor (Pi)*ZZ genotype, in 1 out of 2000 persons, which accounts for 95% of severe AATD cases [1, 10]. This evidence concerns the gene SERPINA1 and alpha 1-antitrypsin deficiency.