In a small cross‐sectional study with 69 AATD individuals carrying variable Pi*alleles, age above 50 years and age at diagnosis above 41 years predicted a FIB‐4 ≥ 1.45 [67], although age is a part of the FIB‐4, making it difficult to tease out the individual effect of other components in FIB‐4 [68]. This evidence concerns the gene SERPINA1 and alpha 1-antitrypsin deficiency.