IGHE and anaphylaxis: The authors concluded that in the absence of an explanation of the sugammadex-IgE-rocuronium-based mechanism, sugammadex is not effective in reversing rocuronium anaphylaxis but effective in some cases of non-rocuronium anaphylaxis by reversing neuromuscular blockade which increases muscle tone compressing intramuscular and intra-abdominal vessels thus reducing venous capacitance, increasing venous return, and cardiac preload [134].