From the TCGA database, we found that in 424 unmatched samples (374 liver cancer tissue samples, 50 adjacent normal tissue samples) (Figure 1A), transcription levels of SREBF2 and some downstream cholesterol metabolism‐related genes (HMGCR, HMGCS1, LDLR, etc.)were mostly higher in cancerous tissues versus adjacent tissues; the transcription levels of selected autophagy‐associated genes were also higher in cancerous tissues than in adjacent tissues. The gene discussed is HMGCR; the disease is liver cancer.