Meanwhile, immunofluorescence data suggested an enhancement in SREBP2 nuclear translocation in cancerous tissues; Filipin III staining and ELISA results exhibited increased cholesterol content in liver cancer tissues versus adjacent tissues, suggesting a significant impact of SREBP2 on the modulation of cholesterol metabolism and autophagy in the occurrence and development of HBV‐associated liver cancer. Here, SREBF2 is linked to liver cancer.