In this study, information from TCGA and GEO databases suggested that the transcription levels of SREBP2 and its downstream key cholesterol regulators, including (HMGCR, HMGCS1, MVK, etc.)as well as the levels of several autophagy‐associated proteins, were up‐regulated in HBV‐associated cancer tissues. The gene discussed is HMGCR; the disease is cancer.