As expected, overexpression of LIMK1‐WT or CDK5‐WT, rather than catalytically inactive mutants (LIMK1‐D460A and CDK5‐K33T), upregulated the expression of mesenchymal markers (fibronectin, N‐cadherin and snail), coupled with a downregulation of the epithelial marker E‐cadherin in ESCC cells (Figure 2D). This evidence concerns the gene FN1 and esophageal squamous cell carcinoma.