High expression of LIMK1 and CDK5 is associated with poor prognosis of ESCC patients, and the clinical and functional significance of LIMK1/CDK5‐Wnt/β‐catenin axis is also verified in esophageal adenocarcinoma, gastric cancer, and lung cancer. The gene discussed is LIMK1; the disease is esophageal squamous cell carcinoma.