ERCC6 plays an essential role in transcription‐coupled nucleotide excision repair, which removes RNA polymerase II‐blocking lesions from active genes’ transcribed strands quickly.[24, 25] Recent research has shown a correlation between ERCC6 expression levels and cancer prognosis.[26] For instance, higher levels of ERCC6 have been associated with poorer outcomes in some cancer types, including gastric cancer,[27] lung cancer,[28] bladder cancer[29] and breast cancer.[30] However, the role of ERCC6 in OS and its cisplatin resistance mechanism remained unclear. Here, ERCC6 is linked to urinary bladder cancer.