Importantly, we highlight mechanisms and observations that translate between the arrays of biologically relevant hyphae and those made with previous versions of the assay, like the role of LTB4 in human neutrophil swarming and the critical role of SYK signaling, while also identifying some which are unique, such as differences in NETosis.10,13,30 By carefully identifying and leveraging the advantages of each target and model system, we will be able to rapidly characterize the molecular mechanisms that regulate swarming and elucidate its role during infection and inflammation in the future. The gene discussed is SYK; the disease is infection.