Since tyrosine is also an inhibitor of protein synthesis and global transcription, it is highly possible that the absence of female sex‐specific molecular pathways, especially estrogen‐mediated pathways, may exacerbate tau and tyrosine‐mediated TyrRS depletion [11], inhibition of tubulin tyrosination, and transcription inhibition, contributing to increased risk of AD [101, 102] and CVDs [173] in post‐menopausal women. Here, YARS1 is linked to Alzheimer disease.