ACHE and Anxiety: Likewise, although acute exposure to cholinergic drugs nicotine, varenicline, and arecoline produces anxiolytic‐like effects in zebrafish (Serikuly et al. 2020; Levin et al. 2007), donepezil (an acetylcholinesterase inhibitor facilitating acetylcholine action) increases anxiety‐like behavior and whole‐body cortisol levels (Giacomini, Bueno, et al. 2020).