Elevating acetylcholine levels by inhibiting hippocampal acetylcholinesterase in mice induces anxiety‐like and depression‐like behaviors (Mineur et al. 2013), whereas oxotremorine (a muscarinic acetylcholine receptor agonist) attenuates anxiety induced by chronic stress (Di Liberto et al. 2017). The gene discussed is ACHE; the disease is depressive disorder.