NFKB1 and infection: Taking advantage of a Drosophila hindgut cell invasion and dissemination model, we pinpoint transcriptional, post-transcriptional, and cellular changes which explain the transition of RasV12 oncogene-expressing hindgut enterocytes regardless of infection from the normal-healthy to an abnormal-invasive state through a crosstalk between the archetypical Toll/NF-κB and Rac1 signalling.