C9orf78 and Alzheimer disease: In this study, they leveraged whole genome sequencing data from the Alzheimer’s disease sequencing project (ADSP) and identified four significant genes: C9orf78, MAF1, NUP93, and GALNT9. This model also iteratively learned the importance of functional annotations to AD and determined that splicing, TF binding, and chromatin state were the most enriched for AD-associated non-coding rare variants74.