In addition to the aforementioned cancers, PDLIM2 has also been linked to infections of the central nervous system, and pathogenic microorganisms that infect the central nervous system can use PDLIM2 to cross the blood-brain barrier, PDLIM2 is also associated with vascular inflammation, rheumatoid arthritis, Laryngeal squamous cell carcinoma,and other diseases, which may present opportunities for additional novel strategies for PDLIM2-targeted therapies for these indications in the future (Table 2) (Li Z. et al., 2021; Wang S. et al., 2022; Yamamoto et al., 2023; Wang P. et al., 2022). This evidence concerns the gene PDLIM2 and central nervous system infectious disorder.