It also stabilizes the blocking cations (Mg2+ and polyamines) in the pore of the Kir2.1 channel (IK1) [29], and long-term exposure to hypokalemia has also been found to accelerate the internalization and degradation of KV11.1 channels [30], collectively decreasing the repolarizing outward K + currents. Here, KCNH2 is linked to Hypokalemia.