By integrating multicohort transcriptomic data (n = 945), we inferred consensus transcriptional regulatory networks (TRNs) and identified six putative transcription factors (PRRX1, TWIST1, SNAI2, MEIS3, VENTX, and EGR2) as robust regulators of THY1. The functional enrichment analysis revealed that these regulators are involved in the epithelial–mesenchymal transition (EMT) and extracellular matrix remodeling, key processes associated with tumor invasion and metastasis. The gene discussed is TWIST1; the disease is neoplasm.