Angptl4, a recently identified adipokine, exerts pleiotropic effects on glucose and lipid metabolism, improves insulin resistance, and is implicated in various risk factors for heart failure, including obesity, diabetes, and coronary heart disease (Xu et al., 2005; Kim et al., 2010; Lichtenstein et al., 2010; Liu et al., 2019). Here, ANGPTL4 is linked to obesity due to melanocortin 4 receptor deficiency.