For instance, integrin-mediated signaling is significantly affected by ECM stiffness, which enhances their activity by promoting the activation of tyrosine-kinase receptors such as EGFR, HER2, vascular endothelial growth factor receptor (VEGFR) and hepatocyte growth factor receptor (HGFR), especially in cancer cells (Guo et al., 2006). Here, MET is linked to cancer.