Ribeiro’s group demonstrated that BPA exposure in ovariectomized mice on high-fat diet exacerbated hepatic steatosis, increasing collagen deposition and altering lipid metabolism genes: downregulating Mttp while upregulating β-oxidation (Acox1, Acadvl), mitochondrial uncoupling (Ucp2), ER stress (Hyou1, Atf6), and liver injury markers (Tgfb1, Casp8). Here, HYOU1 is linked to fatty liver disease.