Herein, we conducted rigor methodology in literature selection (Figure 1): (1) Systematic Search Protocol Databases: We conducted searches in PubMed and MEDLINE using controlled vocabulary (e.g., MeSH terms: “Bisphenols,” “NAFLD,” “Environmental Exposure”) and free-text keywords (e.g., “endocrine disruptors,” “hepatic steatosis,” “PPAR-γ”). The gene discussed is PPARG; the disease is Hepatic steatosis.