Intriguingly, ovariectomized (OVX) HFD-fed females exhibited obesity, glucose intolerance, insulin resistance, and moderate hepatic steatosis, linked to upregulated hepatic lipogenic (Srebf1, Scd1), β-oxidative (Cpt1a), and ER stress (Hspa5, Hyou1) genes (65). Here, HYOU1 is linked to fatty liver disease.