Intriguingly, ovariectomized (OVX) HFD-fed females exhibited obesity, glucose intolerance, insulin resistance, and moderate hepatic steatosis, linked to upregulated hepatic lipogenic (Srebf1, Scd1), β-oxidative (Cpt1a), and ER stress (Hspa5, Hyou1) genes (65). This evidence concerns the gene SREBF1 and Hepatic steatosis.