Univariate analysis of the training set (Table 2) revealed the following parameters to be significantly associated with postoperative DVT: age, sex, smoking, hypertension, diabetes, chronic heart failure, stroke, surgery time, surgical mode, protopathy, intraoperative blood loss, tourniquet use, Preoperative ESR, postoperative NLR (post-NLR), postoperative MLR (post-MLR), postoperative SIRI (post-SIRI), postoperative AISI (post-AISI), postoperative k value (post-k), postoperative alpha (post-α) levels, and postoperative D-dimer (post-D-dimer) levels. The gene discussed is ESR1; the disease is diabetes mellitus.