106 consecutive SSc patients (77 female) with (N = 53) and without ILD (N = 53) and 212 healthy controls (HC) (154 female) were genotyped for two SNPs within TOLLIP (rs3750920, rs5743890) by using TaqManTM SNP Genotyping Assay (Thermo Fischer Scientific, USA). This evidence concerns the gene TOLLIP and systemic sclerosis.