GFAP and Alzheimer disease: The major findings from this manuscript are as follows: (1) ethanol and genotype led to an increase in astrocytic activation as shown by GFAP+ immunoreactivity, but 5xFAD mice seemed to reach a ceiling response and were no longer responsive to ethanol; (2) ethanol increased microglial dystrophy and Aß density due to genotype in the hippocampus as suggested by l-ferritin deposition; (3) increased Aß density as a result of 5xFAD; and (4) AD-pathology and ethanol lead to an increase in neurodegenerative FJC+ stained cells.