In this study, by leveraging DIABLO to integrate and analyze the dynamic changes in the lung transcriptome and metabolome as well as the serum metabolome of mice, we successfully identified specific genes and metabolites associated with influenza progression, including Ccl8, Pdcd1, Gzmk, kynurenine, adipoyl-carnitine, and L-glutamine. Here, CCL8 is linked to influenza.