Notably, our previous research indicated that THBS1 overexpression alleviated surgery-induced osteoarthritis; however, after GPX4 knockout in chondrocytes, THBS1 was unable to effectively reduce osteophyte formation (Supplementary Figures S2E, F), cartilage loss was exacerbated, and cartilage damage severity increased (Supplementary Figures S2G, H). Here, GPX4 is linked to osteoarthritis.