CNR2 and head and neck squamous cell carcinoma: In our previous study led by Chao et al., we demonstrated that THC, a component of marijuana exhibits activation of cannabinoid-specific G protein-coupled receptors (GPCR), CNR1 (Cannabinoid Receptor 1), and CNR2 (Cannabinoid Receptor 2) and drives proliferation and invasion of HPV+ HNSCC via the activation of the mitogen-activated protein kinase (MAPK) pathway (24).