CD274 and neoplasm: Mean CD20 density in tumor of treated group significantly lower than control.Mean CD3 density in tumors was significantly decreased in treated group.Neo rituximab was well-tolerated & decreased B- & T-cell density within high-risk PCa tumors.CD20, CD3 & PD-L1 staining primarily occurred in TLS.Rituximab reduced tumor infiltrating B & T-cell density in TLSs denoting inter-dependence between PCa B & T cells.