Identified up-regulated cytokine & chemokine genes (IL7, LTB & CXCL13) responsible for LN neogenesis correlated with oral cancer-TLS.Improved DFS & OS in patients with higher grades of TLSs.Positive intratumoral (33.8%) and peritumoral (75.4%) TLS detection rates found with intratumoral TLSs significantly associated with decreased P53 & Ki67 scores. The gene discussed is LTB; the disease is lip and oral cavity carcinoma.