Additionally, co-occurrence of tumor-associated CD8+ T cells and CD20+ B cells improves survival in metastatic melanoma patient samples, where TLS in CD8+CD20+ tumors stained for CXCL13, CXCR5, and CD20, and B cell-enriched tumors had increased TCF-7 naive and/or memory T cell levels (111). This evidence concerns the gene CD8A and neoplasm.