CXCL13 colocalizing with TLSs shapes anti-tumor microenvironment by maintenance of CXCR5+CD8+ T cells in TLS.TLS prognostic benefit is only relevant in the presence of CXCL13.High CXCL13 expression associated with prolonged survival.Supports a new CXCL13 & PD-1 blockade clinical trial in HGSOC. Here, CXCL13 is linked to Tumor Lysis Syndrome.