CXCL13 gene expression correlated T & B cells infiltration.CXCL13 was a favorable prognostic factor.CD8+ T cells and B cell lineages in TME significantly improved the prognosis of HGSOC & correlated with presence of TLS.CXCL13 expression coincident with CD4+ T cells in TLS & CD8+ T cells in TILs & shifted from CD4+ T cells to CD21+ follicular DCs as TLS matured. The gene discussed is CD4; the disease is Tumor Lysis Syndrome.