Baseline unswitched memory B cells (NSwM) enriched in R & associated with improved OS and PFS.Tfh cells inversely correlated with IL-6 & CXCL13.BAFF significantly associated with worse OS in discovery & validation cohorts.R were enriched in circulating Tfh cells and TLS.Circulating NSwM B cells positively correlated with Tfh, TLS, and CD20+ B cells at the tumor center & inversely correlated with CXCL13 and BAFF. The gene discussed is IL6; the disease is neoplasm.