High-grade serous ovarian cancer (HGSOC) have a low density of follicular helper T (Tfh) cells resulting in a limited number of mTLS, with accumulation of TIM3+PD-1+, rather than TCF1+PD1+ CD8+ T cells, which may at least in part promote ICI resistance in HGSOC patients (72). This evidence concerns the gene PDCD1 and ovarian serous adenocarcinoma.