By regulating PTEN/AKT pathway, miRNA-19a/b promotesmultidrug resistance (MDR) in gastric cancer cells by accelerating the efflux ofchemotherapeutic drugs and inhibiting drug-induced apoptosis [176, 177].Different members of the miRNA-17-92 family also suppress IL-12 expression bytargeting PTEN to modulate the PI3K-AKT-GSK3 pathway in the immune system [178]. The gene discussed is AKT1; the disease is gastric cancer.