ISL1 and neoplasm: Restoration ofmiRNA-17-92 suppresses the expression of different cell cycle regulatory proteins(cyclin D1, slingshot protein phosphatase 1 (SSH1)), actin cytoskeleton reorganization (LIM domain (Lin-11, Isl-1, and Mec-3) kinase 1 (LIMK1)), RhoGTPase pathway(FYVE, RhoGEF And PH domain containing 4 (FGD4)), which decreases cell proliferation, reduces activation of AKT and microtubule-associated proteins (MAP)kinases, delays tumorigenicity and tumor growth in prostrate tumor-bearing mice[208].