HDAC1 and breast cancer: By targeting sterolregulatory element binding transcription protein 1 (SREBP1), miRNA-18a decreasesthe lung metastasis of breast cancer, which form a co-repressor complex withSNAIL and histone deacetylase 1/2 (HDAC1/2) to modulate EMT (epithelial-mesenchymal transition) [204].