Moreover, the inhibitor of miRNA-17 also improves heart and lung functionin chronic hypoxia-induced pulmonary hypertrophic mice by interfering withpulmonary vascular remodeling and right ventricular hypertrophy via up-regulatingits target, the cyclin-dependent kinase inhibitor 1A (p21) [130]. This evidence concerns the gene CDKN1A and Right ventricular hypertrophy.