The miRNA-17-5p is also associated with pathological cardiac hypertrophy [129].An abnormally high expression of miRNA-17-5p has been identified in the heart oftransverse aortic constriction (TAC)-induced cardiac hypertrophic rats andAng II-induced hypertrophic neonatal rat ventricular myocytes(NRVMs), which targets mitochondrial fusion protein mitofusin 2 (Mfn2)-mediatedPI3K/AKT/mTOR pathway and suppresses autophagy to promote cardiac hypertrophy[129]. This evidence concerns the gene AKT1 and cardiac hypertrophy.