Inhibition of endogenous miRNA-17 via administrationof antagomir in mice enhances expression of tissue inhibitors of metalloproteinases 1 and 2 (TIMP1 and TIMP2) with reduction of matrixmetalloproteinase 9 (MMP9) activity, which leads to reduced post-MI infarct sizeand cardiac dysfunction [88]. The gene discussed is TIMP1; the disease is myocardial infarction.