The results demonstrated a causal relationship between serum ApoB with TB-BMD (β = –0.0424, 95% CI: –0.0746 to –0.0103; p = 0.0096) and LS-BMD (β = –0.0806, 95% CI: –0.1384 to –0.0229; p = 0.0062). The gene discussed is APOB; the disease is tuberculosis.