APOB and osteoporosis: This study stands as the first comprehensive exploration delving into therelationship between serum ApoB and BMD using an epidemiological observationalanalysis with population-wide data and MR studies of large-scale genetic data.These findings support the theory that elevated serum levels of ApoB adverselyaffect bone health and suggests that improving heart function might be animportant target for intervening in osteoporosis associated with elevated ApoBlevels.