Therefore, employing the IVW-MREmethod to assess causality revealed that serum ApoB levels were associated withstroke (ORI⁢V⁢W-M⁢R⁢E = 1.1068, 95% CI: 1.0505 to 1.1662, p = 0.0001),coronary artery disease (ORI⁢V⁢W-M⁢R⁢E = 1.3693, 95% CI: 1.2649 to 1.4822,p = 7.80 × 10-15), heart failure (ORI⁢V⁢W-M⁢R⁢E = 1.0729,95% CI: 1.0202 to 1.1284, p = 0.0062), and peripheral Atherosclerosis(ORI⁢V⁢W-M⁢R⁢E = 1.2790 , 95% CI: 1.2620 to 1.4199, p = 4.88 ×10-15). The gene discussed is APOB; the disease is heart failure.