ZC3H12A and leukemia: While these studies highlight the benefit of Reg-1 KO on improving the function of adoptively transferred T cells, little is known about the efficacy of Reg-1 KO CAR T cells in immune-competent models for solid tumors, with only one study demonstrating the benefit of Reg-1 KO in murine anti-leukemia CD19-CAR T cells11.