Candidate active TFs based on ChromVAR TF activity and expression in 10% of corresponding nuclei were notable for the following: TP63, FOXK1, FOXP1 for basal.SFTPB-1; HNF1B for basal.SFTPB-2; FOXA1, SIX1, SOX4, and KLF5 in goblet; ZEB1 and TCF4 for club-1; GRHL2, JDP2, RUNX1, and IRF2 for club-2; and GRHL1, FOXO3, FOXK1, and FOXP1 for pre-TB-SC. Here, SIX1 is linked to tuberculosis.