TP53 and adenocarcinoma: Here, we performed the first sinonasal in vivo CRISPR screen in mice and surprisingly, rather than unique, distinct sgRNA mutational profiles across sinonasal tumor subtypes, common recurrent NF1/RASA1/TP53 co-mutations across the major sinonasal tumor subtypes including SNSCC, ONB, adenocarcinoma, and SNUC were identified (Figure 2–3).