The downregulation of PHGDH (Fig. 1G and Fig. 2F), a key enzyme often upregulated in other cancer types (Liu et al, 2020; Pacold et al, 2016; Zhang et al, 2023) and non-catalytically expressed lower in cancer dissemination and metastasis (Rossi et al., 2022), underscores PLK1’s unique ability to redirect metabolic flux in prostate cancer. This evidence concerns the gene PLK1 and Familial prostate cancer.