PLK1 and Familial prostate cancer: To confirm the decrease of PHGDH in advanced prostate cancer, we performed the tissue microarray (TMA) of human prostate samples which showed lower level of PHGDH in advanced prostate cancer (Fig. 2C) and immunohistochemistry (IHC) staining for PLK1 overexpressed mouse prostate cancer samples which showed lower level of PHGDH (Fig. 2D).