Although myeloid cells expression of CX3CL1:CX3CR1 may be linked to tumor-promoting activities such as enhanced growth and migration in lung cancer (Okuma et al., 2017; Schmall et al., 2015), CX3CL1:CX3CR1 expression in bulk level is a positive prognostic factor in patients with LUAD (Liu et al., 2019). This evidence concerns the gene CX3CL1 and lung cancer.