In AP rats, necroptosis inhibitors, such as Nec-1, have shown potential in mitigating intestinal damage and barrier dysfunction (Cui et al., 2019), For Hypertriglyceridemic pancreatitis (HTGAP) mouse model, Bacteroides uniformis in the intestine and its metabolite taurine can accelerate the formation of neutrophil extracellular capture NETs (NETs) by activating the NF-κB and IL-17 signaling pathways, ultimately exacerbating pancreatic injury (Li et al., 2023), highlighting a promising avenue for future research. This evidence concerns the gene PCSK1 and alkaline phosphatase measurement.