NFE2L2 and fatty liver disease: QR ameliorates ethanol-induced hepatic steatosis through the modulation of the purinergic 2 × 7 receptor (P2X7R)-mediated PI3K/Keap1/Nrf2 oxidative stress signaling pathway (Zhao et al., 2021), inhibits ROS production and enhances antioxidant enzyme activities, effectively attenuates ethanol metabolism-induced significant upregulation of the mRNA expression of PI3K, Keap1, and Nrf2, enhances the activities of antioxidant enzymes (SOD, GSH, CAT), and reduces the content of lipid peroxidation products (MDA).