QR ameliorates ethanol-induced hepatic steatosis through the modulation of the purinergic 2 × 7 receptor (P2X7R)-mediated PI3K/Keap1/Nrf2 oxidative stress signaling pathway (Zhao et al., 2021), inhibits ROS production and enhances antioxidant enzyme activities, effectively attenuates ethanol metabolism-induced significant upregulation of the mRNA expression of PI3K, Keap1, and Nrf2, enhances the activities of antioxidant enzymes (SOD, GSH, CAT), and reduces the content of lipid peroxidation products (MDA). This evidence concerns the gene KEAP1 and fatty liver disease.