Compensatory upregulation of proteins such as liver fatty acid-binding protein (L-FABP) and microsomal triglyceride transfer protein (MTTP) reflects the intestine’s attempt to manage excess lipid intake but exacerbates systemic dyslipidemia in mice long-term fed on an HFD (Petit et al., 2007). The gene discussed is FABP1; the disease is metabolic syndrome.