While these surgeries are highly effective long-term treatments for severe obesity and type 2 diabetes (Angrisani et al., 2018), evidence suggests that individuals who undergo such procedures face an increased risk of developing AUD (King et al., 2012; 2017; Ibrahim et al., 2019; Maciejewski et al., 2020) despite the significant metabolic changes induced by surgery, including elevated endogenous GLP-1 levels (Larraufie et al., 2019). Here, GLP1R is linked to obesity due to melanocortin 4 receptor deficiency.