Chronic inflammation, including that associated with metabolic syndrome, has been implicated in the occurrence of AF.23 Although high-sensitivity C-reactive protein, white blood cell count, and fibrinogen are commonly utilized as representative markers of chronic inflammation, their utility in predicting recurrence after AF ablation remains a matter of ongoing debate.24 Therefore, a non-targeted analysis of metabolic alterations, including those associated with chronic inflammatory reactions, may provide a more comprehensive insight into its pathophysiology.25 This evidence concerns the gene CRP and atrial fibrillation.