Higher Hb levels within the normal variation range are associated with key components of metabolic syndrome, including hypertension (Auvinen et al., 2021), obesity (Auvinen et al., 2021), non‐alcoholic fatty liver disease (Yu et al., 2012), and insulin resistance (Facchini et al., 1998) and with cardiovascular outcomes such as stroke (Panwar et al., 2016) and CVD mortality (Tapio et al., 2021). The gene discussed is GSTM1; the disease is Hypertension.