Males born to hyperglycemic dams showed decreased AgRP and α‐MSH projections to the PVN, with an increased number of α‐MSH neurons in the ARC in adulthood (Steculorum and Bouret 2011), which are accompanied by hyperphagia, hyperglycemia, and obesity (Steculorum and Bouret 2011). This evidence concerns the gene AGRP and obesity due to melanocortin 4 receptor deficiency.