MC4R and obesity due to melanocortin 4 receptor deficiency: A nonhuman primate model (Macaca fusata) of maternal obesity induced by a 30%‐fat diet showed an increased expression of POMC and MC4R mRNA in the ARC of both male and female offspring during fetal development, accompanied by a decrease in AgRP hypothalamic mRNA expression and fiber density in the PVN (Grayson et al. 2010).