As for the other previous meta‐analysis conducted by Donovan et al., examining a total of 83 921 participants, it reported that lower first‐trimester PAPP‐A (MD −0.17; 95% CI −0.24, −0.10) and free β‐hCG (MD −0.04; 95% CI −0.07 ± 0.01) levels were associated with GDM risk. This evidence concerns the gene PAPPA and gestational diabetes.