2013). In the preferred GATA1 binding site, GATA1 and its partners (SCL, TCF3, LMO2, and LDB1) for the erythroid commitment form on a tandem GATA‐E‐box a cooperative pentameric structure, essential for the specific erythroid genes transcription (Wadman et al. 1997). In accordance, the GATA1 deletion is lethal in embryo mice because of the profound anemia (Pevny et al. 1991). The gene discussed is GATA1; the disease is anemia.