SNCA and Parkinson disease: 2008). GATA1 predominantly activates SNCA transcription in murine erythroid precursor cells by binding a conserved region in the first intron, whereas GATA2 occupies this site in the absence of GATA1 (Scherzer et al. 2008). Interestingly, methylation of SNCA intron 1 has been shown to repress gene expression, and reduced methylation in this region has been observed in the brains of sporadic PD patients (Schmitt et al. 2024).