SNCA and Parkinson disease: 2022). Genetic and transcriptomic analyses have identified GATA2 as a potential driver gene for rapidly progressing PD (PD‐R), associated with metabolic dysfunction, oxidative stress, neuroinflammation, and dysfunctions in the PI3K–Akt pathway, leading to rapid deterioration of motor and non‐motor functions (Su et al. 2024). Moreover, single‐sequence repeat Rep1 has been associated with the development of PD due to the cis‐regulation of SNCA gene by the non‐consensus binding mechanism of GATA2 to SNCA (Afek et al. 2018).