2008). GATA1 predominantly activates SNCA transcription in murine erythroid precursor cells by binding a conserved region in the first intron, whereas GATA2 occupies this site in the absence of GATA1 (Scherzer et al. 2008). Interestingly, methylation of SNCA intron 1 has been shown to repress gene expression, and reduced methylation in this region has been observed in the brains of sporadic PD patients (Schmitt et al. 2024). Here, GATA2 is linked to Parkinson disease.