In contrast, in the Bos taurus native breeds of this study, HCC were similar in S and W and were not correlated with THI of the previous 60 days which evidences that the thermoregulatory mechanisms put forward by these two breeds (ALT and MERT) under HS are independent of cortisol secretion, and HCC is not a reliable biomarker of HS. The gene discussed is GPT; the disease is hepatocellular carcinoma.