Examples include iBD-like isolated and round ulcers in those with haploinsufficiency of A20 (HA20) [35, 36] and celiac-like villous atrophy and lymphocyte infiltration in those with X-linked immune dysregulation, polyendocrinopathy, enteropathy syndrome (IPEX) or IPEX-like syndromes [37, 38]. The gene discussed is TNFAIP3; the disease is immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome.