IL10 and Abnormal intestine morphology: For example, patients with interleukin-10 (IL-10) signaling deficiency (mutations in IL10, IL10RA, or IL10RB) present with very early-onset severe intestinal and perianal disease [7], whereas those with FOXP3 deficiency exhibit multisystem autoimmune symptoms and nonspecific enteropathy with villous atrophy [8].