Abbreviations: IL-10: interleukin-10; IPEX: X-linked immune dysregulation, polyendocrinopathy, enteropathy syndrome; CGD, chronic granulomatous disease; CEAS, chronic enteropathy associated with the SLCO2A1 gene; CNSU, chronic nonspecific multiple ulcers of the small intestine; XLP2, X-linked lymphoproliferative syndrome 2; SD/THES, syndromic diarrhea/tricho-hepato-enteric syndrome; HA20, haploinsufficiency of A20; WAS, Wiskott–Aldrich syndrome;. The gene discussed is XIAP; the disease is chronic granulomatous disease.