The presence of a pathogenic ATTR mutations (HR: 1.73, CI 1.08–2.77, p = 0.02), hypertension (HR: 1.78, CI 1.12–2.94, p = 0.002), and diabetes (HR: 1.95, CI 1.29–2.94, p = 0.02) were significantly associated with HFH but not with death. This evidence concerns the gene TTR and Hypertension.