Comparatively, a lower proportion (35/55, 63.6%) of HG tumours stained positively for CDX2, while 36.4% of HG tumours (e.g., HCT116, SW620, LIM2405 and HCC2998) were negative for CDX2 expression (P < 0.0001, Fisher’s exact test) (Fig. 3B). Here, CDX2 is linked to neoplasm.