In addition to the differences in histology, at the cellular level, loss of differentiation involves loss of cell-cell contacts14 and cell polarity15, while at the molecular level, poorly differentiated tumours display reduced expression of drivers (e.g., CDX2)16 and markers (e.g., VIL1 and KRT20)17,18 of colonic differentiation. This evidence concerns the gene VIL1 and neoplasm.