Although regulation of ribosome biosynthesis may be a primary function by which BUD23 affects asymmetry, recent work has suggested additional roles of BUD23 in that may also contribute to diverse WS phenotypes including regulating glucocorticoid receptor function and target gene histone methylation75, and in facilitating viral infectivity by tethering viral proteins to chromatin76. This evidence concerns the gene NR3C1 and Werner syndrome.