GLS and non-small cell lung carcinoma: Many tumors are reliant on glutamine as a critical carbon and nitrogen source, with glutaminase inhibition shown to be an effective therapy in several cancer types, such as triple-negative breast cancer (Gross et al, 2014), non-small cell lung cancer (van den Heuvel et al, 2012), and head and neck cancer (Wicker et al, 2021).