Additional in vivo data of HIV-1 infection using an alternative hBLT mouse model show an increased relative expression of TIGIT over TIM3 taking place during maturation of adaptive NKG2C+ NK cells in humanized BLT mice infected with HIV-1 that is accompanied by increase of plasma viral load and reduced depletion of CD4+ T cells. This evidence concerns the gene HAVCR2 and HIV-1 infection.