As expected, infected hBLT mice displayed detectable plasma HIV-1 viral loads (pVL) peaking at 2 weeks post-infection (p.i.)(Appendix Fig. S4F, left) and a subsequent reduction in proportions of CD4+ T cells within total CD3+ cells after 3 weeks was observed in infected mice (Appendix Fig. S4F, right), in agreement with kinetics reported in previous studies with this model (Brainard et al, 2009). Here, CD4 is linked to infection.