Given that myeloid lineage cells infiltrating tumours frequently display immunosuppressive properties, it is also noteworthy that in normal kidney there is a ratio of approximately 1.1 myeloid lineage cell for each CD8+ cell, in the ccRCC tumours there are approximately 15 myeloid cells for every CD8+ T cell (Fig. 4d). Here, CD8A is linked to nonpapillary renal cell carcinoma.