We recently created an autochthonous mouse model of ccRCC19 based on the inducible renal epithelial cell-specific (Ksp1.3-CreERT2) deletion of Vhl, Trp53 and Rb1 to model genetic disruption of VHL together with genetic alterations in the cell cycle network that arise in human ccRCC tumours19. This evidence concerns the gene VHL and nonpapillary renal cell carcinoma.