These genes encode CD11b and Ly-6C, respectively, and high cell surface expression of these proteins are flow cytometry markers of mouse monocyte-derived macrophages of M-MDSCs, suggesting that cluster 2 in ccRCC tumours may contain a population of immunosuppressive monocyte-derived macrophage-like cells, hereafter termed Mono-macrophages. The gene discussed is ITGAM; the disease is nonpapillary renal cell carcinoma.