RB1 and nonpapillary renal cell carcinoma: We recently created an autochthonous mouse model of ccRCC19 based on the inducible renal epithelial cell-specific (Ksp1.3-CreERT2) deletion of Vhl, Trp53 and Rb1 to model genetic disruption of VHL together with genetic alterations in the cell cycle network that arise in human ccRCC tumours19.