In contrast, a strong dependency on NRAS-mRNA expression was observed in 81.8% of NRAS-mutant melanoma cell lines (9 of 11) in the CRISPR group and in 66.7% of NRAS-mutant melanoma cell lines (4 of 6) in the RNAi group (Fig. 1b, Supplementary Data 1). This evidence concerns the gene NRAS and melanoma.