Similar to Alzheimer’s disease, with its Amyloid-plaques and tau tangles in the neuronal tissue, which may reduce the functionality of the neuro-vascular unit28, the accumulation of glycosphingolipids may distort the neuro-vascular coupling in severe Fabry’s disease, leading to the unbalanced overemphasized flicker response in Fabry male patients. The gene discussed is MAPT; the disease is Fabry disease.