Given the link between NKL differentiation and AML-induced T-cell dysfunction, we explored the state of TTCR-C4 in patient 8, the only patient of 4 (Supplementary Fig. 5) who exhibited prolonged TTCR-C4 and MRD persistence indicative of disease control despite incomplete leukemia clearance, enabling TTCR-C4/AML interplay analysis. Here, C4A is linked to leukemia.