CD8A and acute myeloid leukemia: To confirm that AML-exposed T cells skewed towards a NKL/Temra rather than exhausted (Tex) phenotype, we projected onto a scRNAseq reference atlas41 a BM AML CD8+ T-cell dataset, compiled from published sources23,25,50–52, alongside datasets representing pancreatic53, melanoma54, and lung55 solid tumors (Supplementary Fig. 23A, B).